Cookies help us deliver our services. By using our services, you agree to our use of cookies.

A novel minimally invasive device for the treatment of coronary artery chronic total occlusions (CTOs)

Clinical Problem: Morality due to myocardial infarctions in the presence of CTOs is ten fold higher than in cases where there is no pre-existing occlusion. Successful treatment of CTOs using current treatment techniques is highly operator dependent and can carry significant adverse effects such as vessel puncture and subsequent intraprocedural death. The development of a novel device could empower less experienced clinicians to achieve more favourable outcomes in CTO percutaneous coronary interventions (PCI) and hence reduce the risk of morbidity and morality associated with myocardial infarctions.


  • Need identification
  • Feasibility analysis
  • Functional analysis
  • Preliminary design
  • Preliminary testing

Timeline: 2018-02-28

Tags: Chronic total occlusions CTO percutaneous coronary interventions PCI coronary Guidewire

Supporting info: CTOs - Current techniques and future directions Subintimal Dissection/Re-entry Strategies for CTOs


Coronary artery chronic total occlusion (CTO) is complete or almost complete blockage of a coronary artery for 30 or more days. Coronary CTO is caused by a heavy build-up of atherosclerotic plaque within the artery. To diagnose a chronic total occlusion, a routine physical exam with a comprehensive medical history is performed. Physicians also may order X-rays, an EKG, stress tests, CT scan, MRI or an angiogram to fully understand your condition. Traditionally, most patients with CTO who have symptoms as noted above required coronary artery bypass graft (CABG) surgery to clear the blockage however the development of specially designed guidewires are allowing cardiologists to bypass or cross blockages [1]. Risk factors for CTOs include: Smoking, family history, high cholesterol, hypertension, overweight, existing cardiovascular disease [1]

A novel minimally invasive device for the treatment of coronary artery chronic total occlusions (CTOs)

Started by Tríona Lally
Thumb 1518189441 picture1

Robbie Gaul

This is really interesting, I have sent you a DM with some potential ideas, let me know what you think.

Thumb user default

Alix Whelan

Hi Triona, I think this clinical need is really interesting and would like to get involved in developing a possible solution. I'm just wondering, do you have any available resources for preliminary feasibility studies or would I have to organise that myself?