Trinity College Dublin
Our research focus is to integrate engineering mechanics into the understanding of the molecular basis of orthopaedic physiology and disease. Our research has discovered novel mechanisms by which bone can sense and respond to a biophysical stimulus. In particular, we are focused on determining indirect and direct biophysical regulation of mesenchymal stem cell contributions to bone formation and repair and how this is altered in disease. These platforms have potential to result in new orthobiologics and biomaterials that mimic the beneficial effect of biophysical stimuli and treat orthopaedic diseases such as osteoporosis and osteoarthritis.
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